Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | MPL | P40238 | 2/20 | 0.37 |
| ▸ | GSK3A | P49840 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | SRPK1 | Q96SB4 | 2/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | MARK3 | P27448 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | FRK | P42685 | 1/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2829501 | 0.86 | GRM5 (0.45) | GRM5NAMPTNOTUM | |
| SCHEMBL2828918 | 0.85 | GRM5 (0.44) | GRM5NAMPT | |
| SCHEMBL2825843 | 0.85 | GRM5 (0.58) | GRM5NAMPT | |
| SCHEMBL2832364 | 0.83 | GRM5 (0.55) | GRM5NAMPT | |
| SCHEMBL2829262 | 0.79 | GRM5 (0.44) | GRM5NAMPT | |
| SCHEMBL2829497 | 0.77 | LMNA (0.49) | GRM5GSK3AGSK3BCSF1RCDK5 | |
| SCHEMBL2831112 | 0.77 | IRAK4 (0.46) | GRM5NAMPTCSF1R | |
| SCHEMBL2824997 | 0.75 | GRM5 (0.48) | GRM5NAMPT | |
| SCHEMBL2827177 | 0.74 | ALDH1A1 (0.46) | GRM5CDK2 | |
| SCHEMBL2830797 | 0.73 | RAB9A (0.51) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |