Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 3/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2825843 | 0.87 | GRM5 (0.58) | GRM5NAMPTNPC1RAB9A | |
| SCHEMBL2829501 | 0.86 | GRM5 (0.45) | GRM5NAMPTRAB9A | |
| SCHEMBL2828918 | 0.85 | GRM5 (0.44) | GRM5PIK3CANAMPTCHRNB2CHRNA4 | |
| SCHEMBL2828432 | 0.83 | GRM5 (0.42) | GRM5NAMPT | |
| SCHEMBL2829262 | 0.81 | GRM5 (0.44) | GRM5PIK3CANAMPTMAPT | |
| SCHEMBL2831112 | 0.79 | IRAK4 (0.46) | GRM5NAMPTMAPTPKM | |
| SCHEMBL2830049 | 0.77 | GRM5 (0.60) | GRM5PIK3CANAMPTMAPT | |
| SCHEMBL2824997 | 0.77 | GRM5 (0.48) | GRM5NAMPTNPC1MAPTRAB9A | |
| SCHEMBL2829497 | 0.77 | LMNA (0.49) | GRM5NPC1MAPTRAB9A | |
| SCHEMBL2829704 | 0.76 | GRM5 (0.57) | GRM5NPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |