Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 8/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826867 | 0.88 | CDK4 (0.45) | GRM5CDK4CDK2NPC1RAB9A | |
| SCHEMBL2828101 | 0.86 | GRM5 (0.48) | GRM5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2829312 | 0.86 | GRM5 (0.52) | GRM5PIK3CGCDK4CDK2NPC1 | |
| SCHEMBL2830286 | 0.86 | GRM5 (0.40) | GRM5PIK3CGCDK4CDK2NPC1 | |
| SCHEMBL2829847 | 0.85 | GRM5 (0.52) | GRM5KCNH2 | |
| SCHEMBL2830257 | 0.85 | GRM5 (0.50) | GRM5SORT1 | |
| SCHEMBL2830057 | 0.84 | GRM5 (0.38) | GRM5SORT1 | |
| SCHEMBL2826585 | 0.83 | GRM5 (0.52) | GRM5JAK2JAK3PIK3CG | |
| SCHEMBL2825999 | 0.80 | LMNA (0.41) | GRM5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2833176 | 0.80 | SORT1 (0.41) | GRM5JAK2JAK1SORT1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |