Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.54 |
| ▸ | HTR5A | P47898 | 6/20 | 0.54 |
| ▸ | HTR1A | P08908 | 5/20 | 0.54 |
| ▸ | HTR1D | P28221 | 5/20 | 0.54 |
| ▸ | HTR7 | P34969 | 5/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18574032 | 0.74 | HTR5A (0.40) | HTR2CHTR5AHTR1AHTR1DHTR7 | |
| SCHEMBL5696196 | 0.74 | DHFR (0.51) | HTR2CHTR5AHTR1AHTR1DHTR7 | |
| SCHEMBL30528605 | 0.68 | HTR5A (0.58) | HTR5ACREBBP | |
| SCHEMBL2832579 | 0.68 | HTR5A (0.58) | HTR5ACREBBP | |
| SCHEMBL14765174 | 0.65 | CREBBP (0.54) | HTR2CHTR5AHTR1AHTR1DHTR7 | |
| SCHEMBL14765075 | 0.65 | CREBBP (0.54) | HTR2CHTR5AHTR1AHTR1DHTR7 | |
| SCHEMBL2827127 | 0.64 | HTR1A (0.54) | HTR2CHTR5AHTR1AHTR1DHTR7 | |
| SCHEMBL10716481 | 0.64 | HTR2C (0.46) | HTR2CHTR5AHTR1AHTR1DHTR7 | |
| SCHEMBL1382388 | 0.64 | HTR2C (0.49) | HTR2CHTR5AHTR1AHTR1DHTR7 | |
| SCHEMBL1321330 | 0.64 | HTR2C (0.46) | HTR2CHTR5AHTR1AHTR1DHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7790733-B2 | 8-alkoxy or cycloalkoxy-4-methyl-3,4-dihydro-quinazolin-2-ylamines | HOFFMAN-LA ROCHE INC. (US) | 2010-09-07 | — | — | US | disclosed |
| EP-1899307-B1 | 8-ALK0XY-4-METHYL-3, 4-DIHYDR0-QUINAZ0LIN-2-YL AMINES AND THEIR USE AS 5-HT5A RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2010-06-30 | — | — | EP | disclosed |
| EP-1899307-A1 | 8-ALK0XY-4-METHYL-3, 4-DIHYDR0-QUINAZ0LIN-2-YL AMINES AND THEIR USE AS 5-HT5A RECEPTOR LIGANDS | F. Hoffmann-Roche AG (CH) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007000393-A1 | 8-ALK0XY-4-METHYL-3 , 4-DIHYDR0-QUINAZ0LIN-2-YL AMINES AND THEIR USE AS 5-HT5A RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-01-04 | — | — | WO | disclosed |
| US-20060293350-A1 | 8-Alkoxy or cycloalkoxy-4-methyl-3,4-dihydro-quinazolin-2-ylamines | F. HOFFMANN-LA ROCHE AG A SWISS COMPANY (CH) | 2006-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060293350-A1 | 8-Alkoxy or cycloalkoxy-4-methyl-3,4-dihydro-quinazolin-2-ylamines | HTR5A, HTR2C, HTR3A | HTR2C 2/4885HTR5A 1/4885HTR1A 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.