SCHEMBL28294766

SCHEMBL28294766

CCOC(=O)C(C#N)(Cc1ccccc1)C(CC)c1ccc(C#N)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.42
RECQL P46063 1/20 0.42
MMP8 P22894 1/20 0.42
CTSG P08311 6/20 0.40
CMA1 P23946 5/20 0.39
PRSS1 P07477 2/20 0.38
CTRB1 P17538 2/20 0.38
FFAR1 O14842 1/20 0.38
MAOB P27338 1/20 0.37
SLC1A3 P43003 1/20 0.36
SLC1A2 P43004 1/20 0.36
L3MBTL1 Q9Y468 2/20 0.36
KDM4E B2RXH2 1/20 0.36
GAA P10253 1/20 0.36
MAPT P10636 1/20 0.36
KMT2A Q03164 1/20 0.36
CYP11B1 P15538 1/20 0.36
CYP11B2 P19099 1/20 0.36
LMNA P02545 1/20 0.36
CNR2 P34972 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28296480 0.89 MMP8 (0.44) ALDH1A1RECQLMMP8L3MBTL1GAA
SCHEMBL28873305 0.89 ALDH1A1 (0.42) ALDH1A1RECQLMMP8L3MBTL1KDM4E
SCHEMBL28296475 0.89 ALDH1A1 (0.42) ALDH1A1RECQLMMP8L3MBTL1KDM4E
SCHEMBL28294787 0.79 ALDH1A1 (0.42) ALDH1A1KDM4EKMT2ALMNA
SCHEMBL28796243 0.77 ALDH1A1 (0.48) ALDH1A1RECQLMMP8CTSGCMA1
SCHEMBL7942748 0.71 ALDH1A1 (0.55) ALDH1A1RECQLMMP8L3MBTL1MAPT
SCHEMBL23699289 0.70 MMP8 (0.57) ALDH1A1RECQLMMP8L3MBTL1MAPT
SCHEMBL29277135 0.70 ALDH1A1 (0.54) ALDH1A1RECQLMMP8L3MBTL1GAA
SCHEMBL29277106 0.70 CYP2A6 (0.44) ALDH1A1RECQLMMP8L3MBTL1KDM4E
SCHEMBL5201387 0.68 SMN1; SMN2 (0.42) ALDH1A1RECQLMMP8L3MBTL1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109694334-A The non-solvent preparation of disubstituted cyanoacetic acid ester compounds 西华大学 2019-04-30 CN disclosed