SCHEMBL28296475

SCHEMBL28296475

CCOC(=O)C(C#N)(Cc1ccccc1)C(CC)c1ccc(F)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.42
RECQL P46063 1/20 0.42
MMP8 P22894 1/20 0.42
KMT2A Q03164 3/20 0.39
MAPK1 P28482 1/20 0.39
KDM4E B2RXH2 2/20 0.37
CACNA1G O43497 1/20 0.37
HPGD P15428 4/20 0.36
LMNA P02545 3/20 0.36
NPSR1 Q6W5P4 3/20 0.36
MAPT P10636 2/20 0.36
MEN1 O00255 2/20 0.36
ALOX12 P18054 1/20 0.36
CCR6 P51684 1/20 0.36
HKDC1 Q2TB90 1/20 0.36
KDM4C Q9H3R0 1/20 0.36
SMN1; SMN2 Q16637 3/20 0.36
GPR55 Q9Y2T6 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
USP2 O75604 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28873305 0.89 ALDH1A1 (0.42) ALDH1A1RECQLMMP8KMT2AKDM4E
SCHEMBL28296480 0.89 MMP8 (0.44) ALDH1A1RECQLMMP8KMT2ALMNA
SCHEMBL28294766 0.89 ALDH1A1 (0.42) ALDH1A1RECQLMMP8KMT2AKDM4E
SCHEMBL28294787 0.79 ALDH1A1 (0.42) ALDH1A1KMT2AKDM4ELMNAMEN1
SCHEMBL28796267 0.78 ALDH1A1 (0.49) ALDH1A1RECQLMMP8KMT2AMAPK1
SCHEMBL7942748 0.74 ALDH1A1 (0.55) ALDH1A1RECQLMMP8KMT2ALMNA
SCHEMBL23699289 0.70 MMP8 (0.57) ALDH1A1RECQLMMP8KMT2ALMNA
SCHEMBL29277135 0.70 ALDH1A1 (0.54) ALDH1A1RECQLMMP8KMT2ALMNA
SCHEMBL28796256 0.69 ALDH1A1 (0.47) ALDH1A1RECQLMMP8KMT2AKDM4E
SCHEMBL9685954 0.68 ALDH1A1 (0.51) ALDH1A1RECQLMMP8KMT2AMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109694334-A The non-solvent preparation of disubstituted cyanoacetic acid ester compounds 西华大学 2019-04-30 CN disclosed