Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.51 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.50 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.46 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28175732 | 0.87 | PIK3CA (0.53) | TLR8KDM4ENPSR1CCNB2CDK1 | |
| SCHEMBL16549166 | 0.84 | CCNB2 (0.49) | TLR8DYRK1AKDM4EMAPK1NPSR1 | |
| SCHEMBL16549227 | 0.84 | MAP4K4 (0.50) | TLR8DYRK1ACYP19A1SYKKDM4E | |
| SCHEMBL28295739 | 0.81 | PIK3CA (0.48) | GRM2KDM4ENPSR1CCNB2CDK1 | |
| SCHEMBL10157305 | 0.80 | PIK3CA (0.57) | TLR8KDM4EMAPK1NPSR1PIK3CA | |
| SCHEMBL30440258 | 0.80 | PIK3CA (0.57) | TLR8KDM4EMAPK1NPSR1PIK3CA | |
| SCHEMBL7665284 | 0.80 | BMP4 (0.61) | TLR8SYKKDM4ENPSR1MAPT | |
| SCHEMBL30251801 | 0.80 | BMP4 (0.61) | TLR8SYKKDM4ENPSR1MAPT | |
| SCHEMBL28293866 | 0.79 | PIK3CA (0.46) | KDM4ENPSR1PIK3CAMAPTLMNA | |
| SCHEMBL29287969 | 0.76 | PIK3CA (0.49) | KDM4ENPSR1PIK3CAMAPTMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109796403-B | Quinoline derivatives and preparation method thereof | 安徽师范大学 | 2021-09-28 | — | — | CN | disclosed |
| CN-109796403-A | Quinoline derivatives and preparation method thereof | 安徽师范大学 | 2019-05-24 | — | — | CN | disclosed |