Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 5/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7113070 | 0.70 | PKM (0.61) | PKMMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL7005474 | 0.68 | MEN1 (0.53) | PKMMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6997732 | 0.68 | SMN1; SMN2 (0.56) | PKMMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL28020015 | 0.68 | MAPT (0.43) | PKMMAPTSMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL4501948 | 0.68 | PKM (1.00) | PKMMAPTSMN1; SMN2ALDH1A1POLB | |
| SCHEMBL28693875 | 0.67 | PKM (0.61) | PKMMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL27244243 | 0.67 | SMN1; SMN2 (0.37) | PKMMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6999112 | 0.66 | MEN1 (0.51) | PKMMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL28876232 | 0.66 | GABRA1 (0.40) | MAPTGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL19207123 | 0.65 | KMT2A (0.48) | MAPTGABRA1GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109721589-A | A kind of aniline imidazolyl pyrimidines aminated compounds, preparation method and purposes with anti-tumor activity | 如东凌达生物医药科技有限公司 | 2019-05-07 | — | — | CN | disclosed |
| CN-109721600-A | A kind of nitrogenous fused ring compound and its preparation method and application | 如东凌达生物医药科技有限公司 | 2019-05-07 | — | — | CN | disclosed |