Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | MITF | O75030 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3528459 | 0.80 | CA12 (0.40) | ALDH1A1CA12CA1CA2CA3 | |
| SCHEMBL9842300 | 0.78 | KAT6A (0.42) | KDM4EALDH1A1SMN1; SMN2LMNACA12 | |
| SCHEMBL28282439 | 0.78 | CA2 (0.52) | SMN1; SMN2MAPK1MAPTTP53CA12 | |
| SCHEMBL5890969 | 0.74 | LMNA (0.64) | KDM4ERAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL5891165 | 0.74 | LMNA (0.64) | KDM4ERAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL19627024 | 0.73 | ALDH1A1 (0.72) | KDM4ERAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL17626247 | 0.73 | KDM4E (0.46) | KDM4ERAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL13930336 | 0.73 | KDM4E (0.59) | KDM4ERAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL10284703 | 0.71 | KMT2A (0.48) | KDM4ERAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL19625388 | 0.70 | KDM4E (0.55) | KDM4ERAB9AALDH1A1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109776537-A | Purinedione as WNT pathway modulators | 新加坡科技研究局 | 2019-05-21 | — | — | CN | disclosed |