SCHEMBL28796256

SCHEMBL28796256

CCOC(=O)C(C#N)(Cc1ccccc1)Cc1ccc(OC)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.47
RECQL P46063 1/20 0.47
MMP8 P22894 1/20 0.47
MMP1 P03956 2/20 0.43
MMP13 P45452 2/20 0.43
LTA4H P09960 1/20 0.43
ALOX5 P09917 2/20 0.42
CACNA1G O43497 1/20 0.42
KMT2A Q03164 4/20 0.42
NPC1 O15118 2/20 0.42
GLA P06280 1/20 0.42
MEN1 O00255 3/20 0.42
TDP1 Q9NUW8 2/20 0.42
KDM4E B2RXH2 1/20 0.42
LMNA P02545 1/20 0.42
MAPT P10636 1/20 0.42
HPGD P15428 1/20 0.42
HTT P42858 1/20 0.42
CCR6 P51684 1/20 0.42
HKDC1 Q2TB90 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7942748 0.91 ALDH1A1 (0.55) ALDH1A1RECQLMMP8KMT2AMEN1
SCHEMBL28796267 0.87 ALDH1A1 (0.49) ALDH1A1RECQLMMP8CACNA1GKMT2A
SCHEMBL28796243 0.86 ALDH1A1 (0.48) ALDH1A1RECQLMMP8KMT2ASNCA
SCHEMBL28796282 0.86 MMP8 (0.51) ALDH1A1RECQLMMP8KMT2AMEN1
SCHEMBL28796264 0.86 ALDH1A1 (0.48) ALDH1A1RECQLMMP8KMT2AMEN1
SCHEMBL28796335 0.81 AR (0.44) ALDH1A1RECQLMMP8KMT2ATDP1
SCHEMBL9555278 0.79 PTPN1 (0.47) ALDH1A1RECQLMMP8KMT2AMEN1
SCHEMBL28873305 0.79 ALDH1A1 (0.42) ALDH1A1RECQLMMP8CACNA1GKMT2A
SCHEMBL29048912 0.79 MMP8 (0.46) ALDH1A1RECQLMMP8KMT2AMEN1
SCHEMBL6800776 0.77 MMP1 (0.43) ALDH1A1MMP8MMP1MMP13LTA4H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109694334-B Solvent-free preparation method of disubstituted cyanoacetate compound 西华大学 2022-07-22 CN disclosed