SCHEMBL28296727

SCHEMBL28296727

CCOC(=O)C(C#N)(CCCc1ccc(Cl)cc1)Cc1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR1 P32246 1/20 0.43
ALDH1A1 P00352 1/20 0.42
RECQL P46063 1/20 0.42
MMP8 P22894 1/20 0.42
GPR119 Q8TDV5 5/20 0.41
PPARA Q07869 3/20 0.39
PPARG P37231 2/20 0.39
PTPRC P08575 1/20 0.39
PTPN2 P17706 1/20 0.39
PTPN1 P18031 1/20 0.39
PTPRB P23467 1/20 0.39
PTPRG P23470 1/20 0.39
ACP1 P24666 1/20 0.39
OPRK1 P41145 1/20 0.39
ABCB11 O95342 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
TSHR P16473 1/20 0.39
HTR2A P28223 1/20 0.39
PMP22 Q01453 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28796264 0.90 ALDH1A1 (0.48) CCR1ALDH1A1RECQLMMP8GPR119
SCHEMBL29048912 0.82 MMP8 (0.46) CCR1ALDH1A1RECQLMMP8L3MBTL1
SCHEMBL7942748 0.82 ALDH1A1 (0.55) ALDH1A1RECQLMMP8TSHRL3MBTL1
SCHEMBL11357970 0.81 CYP3A4 (0.42) CCR1ALDH1A1GPR119PPARAOPRK1
SCHEMBL11349337 0.79 CYP3A4 (0.44) CCR1ALDH1A1RECQLMMP8GPR119
SCHEMBL28796267 0.78 ALDH1A1 (0.49) ALDH1A1RECQLMMP8L3MBTL1
SCHEMBL28796282 0.77 MMP8 (0.51) ALDH1A1RECQLMMP8PTPN2PTPN1
SCHEMBL28796243 0.77 ALDH1A1 (0.48) ALDH1A1RECQLMMP8
SCHEMBL28796256 0.76 ALDH1A1 (0.47) ALDH1A1RECQLMMP8TDP1L3MBTL1
SCHEMBL11275037 0.76 PPARA (0.48) ALDH1A1RECQLMMP8GPR119PPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109694334-A The non-solvent preparation of disubstituted cyanoacetic acid ester compounds 西华大学 2019-04-30 CN disclosed