SCHEMBL28796282

SCHEMBL28796282

CCOC(=O)C(C#N)(Cc1ccccc1)Cc1ccc(Br)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP8 P22894 2/20 0.51
ALDH1A1 P00352 2/20 0.48
RECQL P46063 1/20 0.48
PIN1 Q13526 1/20 0.40
SMN1; SMN2 Q16637 3/20 0.40
LMNA P02545 3/20 0.40
NPSR1 Q6W5P4 2/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
CYP19A1 P11511 1/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
PDE3B Q13370 1/20 0.38
PDE3A Q14432 1/20 0.38
TAS2R14 Q9NYV8 1/20 0.38
PPID Q08752 1/20 0.37
PTPN2 P17706 1/20 0.37
PTPN1 P18031 1/20 0.37
PTPRB P23467 1/20 0.37
ACP1 P24666 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7942748 0.92 ALDH1A1 (0.55) MMP8ALDH1A1RECQLPIN1SMN1; SMN2
SCHEMBL28796267 0.88 ALDH1A1 (0.49) MMP8ALDH1A1RECQLPIN1SMN1; SMN2
SCHEMBL28796243 0.87 ALDH1A1 (0.48) MMP8ALDH1A1RECQLPIN1KMT2A
SCHEMBL28796264 0.87 ALDH1A1 (0.48) MMP8ALDH1A1RECQLPIN1LMNA
SCHEMBL28796256 0.86 ALDH1A1 (0.47) MMP8ALDH1A1RECQLLMNANPSR1
SCHEMBL28796335 0.83 AR (0.44) MMP8ALDH1A1RECQLSMN1; SMN2LMNA
SCHEMBL29048912 0.80 MMP8 (0.46) MMP8ALDH1A1RECQLPIN1SMN1; SMN2
SCHEMBL29277135 0.79 ALDH1A1 (0.54) MMP8ALDH1A1RECQLPIN1SMN1; SMN2
SCHEMBL28296480 0.77 MMP8 (0.44) MMP8ALDH1A1RECQLPIN1SMN1; SMN2
SCHEMBL28296727 0.77 CCR1 (0.43) MMP8ALDH1A1RECQLCYP1A2L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109694334-B Solvent-free preparation method of disubstituted cyanoacetate compound 西华大学 2022-07-22 CN disclosed