SCHEMBL28296746

SCHEMBL28296746

COCOc1cc[c]c(Br)c1

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FYN P06241 2/20 0.31
MAOB P27338 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27688593 0.84 FBP1 (0.35) MAOB
SCHEMBL1637027 0.81 NQO1 (0.44)
SCHEMBL980218 0.78
SCHEMBL27868660 0.78 FYN (0.33) FYN
SCHEMBL6655416 0.78 GRM5 (0.31) FYNMAOB
SCHEMBL27655749 0.76 ROR1 (0.30) FYN
SCHEMBL27754179 0.76 KCNA3 (0.31) MAOB
SCHEMBL8090510 0.75 TSHR (0.46)
SCHEMBL28051634 0.75 FYN (0.32) FYN
SCHEMBL6527639 0.74 MMP2 (0.31) FYN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111989321-B KRAS G12C inhibitors 米拉蒂治疗股份有限公司 2024-05-14 CN disclosed
CN-114615981-B KRAS G12D inhibitors 米拉蒂治疗股份有限公司 2024-04-12 CN disclosed
CN-109843856-B KRAS G12C inhibitors 米拉蒂治疗股份有限公司 2023-05-02 CN disclosed
CN-114615981-A KRAS G12D inhibitors 米拉蒂治疗股份有限公司 2022-06-10 CN disclosed
CN-111989321-A KRAS G12C inhibitors 米拉蒂治疗股份有限公司 2020-11-24 CN disclosed
CN-109843856-A KRAS G12C inhibitor 米拉蒂治疗股份有限公司 2019-06-04 CN disclosed