⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28296746 | 0.78 | FYN (0.31) | — | |
| SCHEMBL28542391 | 0.77 | ALDH1A1 (0.39) | — | |
| SCHEMBL1637027 | 0.77 | NQO1 (0.44) | — | |
| SCHEMBL27688593 | 0.77 | FBP1 (0.35) | — | |
| SCHEMBL15066961 | 0.76 | ALDH1A1 (0.41) | — | |
| SCHEMBL6978764 | 0.75 | CHRM2 (0.47) | — | |
| SCHEMBL160135 | 0.74 | — | — | |
| SCHEMBL77754 | 0.74 | CA1 (0.39) | — | |
| SCHEMBL1067722 | 0.74 | ALOX15 (0.39) | — | |
| SCHEMBL28084471 | 0.74 | LMNA (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 201 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11351178-B2 | Selective HDAC6 inhibitors | ITALFARMACO SPA (IT) | 2022-06-07 | — | — | US | claimed |
| US-20210128577-A1 | Selective HDAC6 Inhibitors | ITALFARMACO S.P.A. (IT) | 2021-05-06 | — | — | US | claimed |
| CN-110642918-B | Diosgenin derivative and preparation method and application thereof | 山东师范大学 | 2021-01-08 | — | — | CN | claimed |
| CN-110642918-A | Diosgenin derivative and preparation method and application thereof | 山东师范大学 | 2020-01-03 | — | — | CN | claimed |
| CN-110546140-A | selective HDAC6 inhibitors | ITALFARMACO SPA | 2019-12-06 | — | — | CN | claimed |
| EP-3562810-A1 | SELECTIVE HDAC6 INHIBITORS | Italfarmaco SpA (IT) | 2019-11-06 | — | — | EP | claimed |
| WO-2018189340-A1 | SELECTIVE HDAC6 INHIBITORS | ITALFARMACO S.P.A. (IT) | 2018-10-18 | — | — | WO | claimed |
| EP-2257167-B1 | 2-AMINOIMIDAZOLE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME (US) | 2015-07-22 | — | — | EP | claimed |
| WO-2014002109-A1 | SUBSTITUTED TETRAZOLE COMPOUNDS AND PROCESS THEREOF | RALLIS INDIA LIMITED (IN) | 2014-01-03 | — | — | WO | claimed |
| US-8492387-B2 | 2-aminoimidazole beta-secretase inhibitors for the treatment of alzheimer's disease | Merck, Sharp & Dohme, Corp. (US) | 2013-07-23 | — | — | US | claimed |
| WO-2012164572-A1 | SUBSTITUTED 4-ARYLTHIAZOLES AND PROCESS OF PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2012-12-06 | — | — | WO | claimed |
| US-20110034483-A1 | 2-AMINOIMIDAZOLE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | Via EFS | 2011-02-10 | — | — | US | claimed |
| EP-2257167-A1 | 2-AMINOIMIDAZOLE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | Merck Sharp & Dohme Corp. (US) | 2010-12-08 | — | — | EP | claimed |
| WO-2009108550-A1 | 2-AMINOIMIDAZOLE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK & CO., INC. (US) | 2009-09-03 | — | — | WO | claimed |
| CN-118255627-A | Growth nutrient solution for cultivating passion fruit in barren soil | 漳州城市职业学院 | 2024-06-28 | — | — | CN | disclosed |
| CN-118265453-A | Protein aggregation inhibiting compounds for plant disease control | 马克斯·普朗克科学促进学会 | 2024-06-28 | — | — | CN | disclosed |
| US-11970486-B2 | Compounds and uses thereof | JANSSEN PHARMACEUTICA NV (BE) | 2024-04-30 | — | — | US | disclosed |
| EP-0320733-A2 | 2-tert.-butyl-5-isoxazolyl methylthio-3(2H)-pyridazin-3-one derivatives | BASF Aktiengesellschaft (DE) | 1989-06-21 | — | — | EP | disclosed |
| US-4824834-A | TREATING GOUT | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1989-04-25 | — | — | US | disclosed |
| EP-0269859-A2 | Pyrazolotriazine compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-06-08 | — | — | EP | disclosed |