Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 2/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | GRM8 | O00222 | 1/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
| ▸ | F3 | P13726 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17596760 | 0.94 | TBXAS1 (0.60) | TBXAS1EPHX2CYP2C9CYP2C19LMNA | |
| SCHEMBL8775812 | 0.79 | TBXAS1 (0.65) | TBXAS1EPHX2CYP2C9CYP2C19LMNA | |
| SCHEMBL2091811 | 0.79 | HRH1 (0.52) | EPHX2CYP2C19LMNASMN1; SMN2SLC6A3 | |
| SCHEMBL17591689 | 0.78 | LMNA (0.54) | TBXAS1CYP2C19LMNAGRM8GRM4 | |
| SCHEMBL3431967 | 0.78 | TBXAS1 (0.44) | TBXAS1EPHX2CYP2C9CYP2C19LMNA | |
| SCHEMBL8775857 | 0.78 | TBXAS1 (0.63) | TBXAS1EPHX2CYP2C9CYP2C19LMNA | |
| Hydrochloric Acid SCHEMBL28569021 | 0.77 | HRH1 (0.50) | EPHX2CYP2C19LMNASMN1; SMN2SLC6A3 | |
| SCHEMBL28085892 | 0.75 | TBXAS1 (0.49) | TBXAS1EPHX2CYP2C9CYP2C19LMNA | |
| SCHEMBL8775861 | 0.74 | TBXAS1 (0.56) | TBXAS1EPHX2CYP2C9CYP2C19LMNA | |
| SCHEMBL2203786 | 0.73 | CYP2C19 (0.56) | EPHX2CYP2C19LMNASMN1; SMN2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104837832-B | GDF-8 inhibitors | 里格尔药品股份有限公司 | 2019-04-26 | — | — | CN | claimed |
| CN-104837832-A | GDF-8 inhibitors | RIGEL PHARMACEUTICALS INC | 2015-08-12 | — | — | CN | claimed |
| CN-104837832-A | GDF-8 inhibitors | RIGEL PHARMACEUTICALS INC | 2015-08-12 | — | — | CN | disclosed |