SCHEMBL28297096

SCHEMBL28297096

O=CC(=O)C1CCc2cc(Cl)c(Cl)cc21

nearest known ligand 0.43

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 3/20 0.36
HTR2C P28335 3/20 0.36
HTR2B P41595 3/20 0.36
FABP4 P15090 10/20 0.33
MAP4K4 O95819 2/20 0.31
PDE5A O76074 1/20 0.31
CYP19A1 P11511 1/20 0.31
HSD17B1 P14061 1/20 0.31
FABP3 P05413 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8834341 0.81 FABP4 (0.45) HTR2AHTR2CHTR2BFABP4MAP4K4
SCHEMBL8562224 0.81 HTR2A (0.39) HTR2AHTR2CHTR2BFABP4MAP4K4
SCHEMBL8834452 0.81 FABP4 (0.45) HTR2AHTR2CHTR2BFABP4MAP4K4
SCHEMBL28295382 0.74 DRD2 (0.38) HTR2CHTR2B
SCHEMBL11186965 0.73 FABP4 (0.43) FABP4MAP4K4PDE5AFABP3
SCHEMBL27530867 0.72 PIN1 (0.55)
SCHEMBL28297098 0.71 MTNR1A (0.52)
SCHEMBL30686717 0.69 HTR2A (0.43) HTR2AHTR2CHTR2BCYP19A1HSD17B1
SCHEMBL9251756 0.69 HTR2A (0.43) HTR2AHTR2CHTR2BCYP19A1HSD17B1
Maleic Acid SCHEMBL11577738 0.68 DRD2 (0.39) HTR2AHTR2CHTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109666288-A New methine dyes 朗盛德国有限责任公司 2019-04-23 CN disclosed