Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | ACP3 | P15309 | 3/20 | 0.56 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.54 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | CA4 | P22748 | 1/20 | 0.52 |
| ▸ | CA5A | P35218 | 1/20 | 0.52 |
| ▸ | MMP8 | P22894 | 2/20 | 0.50 |
| ▸ | MMP14 | P50281 | 2/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.48 |
| ▸ | MMP3 | P08254 | 1/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | CFTR | P13569 | 1/20 | 0.46 |
| ▸ | FDPS | P14324 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | IDH1 | O75874 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL28301373 | 1.00 | ALDH1A1 (0.56) | ALDH1A1ACP3PTPN5CA2CA4 | |
| Biphenyl SCHEMBL1945860 | 0.97 | ALDH1A1 (0.60) | ALDH1A1ACP3PTPN5CA2CA4 | |
| Biphenyl SCHEMBL3727875 | 0.97 | ALDH1A1 (0.60) | ALDH1A1ACP3PTPN5CA2CA4 | |
| Biphenyl SCHEMBL342228 | 0.97 | ALDH1A1 (0.60) | ALDH1A1ACP3PTPN5CA2CA4 | |
| Biphenyl SCHEMBL263925 | 0.97 | ALDH1A1 (0.60) | ALDH1A1ACP3PTPN5CA2CA4 | |
| Biphenyl SCHEMBL3763955 | 0.97 | ALDH1A1 (0.60) | ALDH1A1ACP3PTPN5CA2CA4 | |
| Biphenyl SCHEMBL27485598 | 0.97 | ALDH1A1 (0.60) | ALDH1A1ACP3PTPN5CA2CA4 | |
| Biphenyl SCHEMBL19244130 | 0.94 | ALDH1A1 (0.56) | ALDH1A1ACP3PTPN5CA2CA4 | |
| Biphenyl SCHEMBL11128267 | 0.94 | ALDH1A1 (0.56) | ALDH1A1ACP3PTPN5CA2CA4 | |
| Biphenyl SCHEMBL356478 | 0.94 | ALDH1A1 (0.56) | ALDH1A1ACP3PTPN5CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109762403-A | A kind of environmentally friendly buckling type steelwork fireproof coating | 北京理工大学珠海学院 | 2019-05-17 | — | — | CN | disclosed |