Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | ACP3 | P15309 | 3/20 | 0.56 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.54 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | CA4 | P22748 | 1/20 | 0.52 |
| ▸ | CA5A | P35218 | 1/20 | 0.52 |
| ▸ | MMP8 | P22894 | 2/20 | 0.50 |
| ▸ | MMP14 | P50281 | 2/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.48 |
| ▸ | MMP3 | P08254 | 1/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | CFTR | P13569 | 1/20 | 0.46 |
| ▸ | FDPS | P14324 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | IDH1 | O75874 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL263925 | 0.97 | ALDH1A1 (0.60) | ALDH1A1ACP3PTPN5CA2CA4 | |
| Biphenyl SCHEMBL27485598 | 0.97 | ALDH1A1 (0.60) | ALDH1A1ACP3PTPN5CA2CA4 | |
| Biphenyl SCHEMBL1945860 | 0.97 | ALDH1A1 (0.60) | ALDH1A1ACP3PTPN5CA2CA4 | |
| Biphenyl SCHEMBL3727875 | 0.97 | ALDH1A1 (0.60) | ALDH1A1ACP3PTPN5CA2CA4 | |
| Biphenyl SCHEMBL342228 | 0.97 | ALDH1A1 (0.60) | ALDH1A1ACP3PTPN5CA2CA4 | |
| Biphenyl SCHEMBL3763955 | 0.97 | ALDH1A1 (0.60) | ALDH1A1ACP3PTPN5CA2CA4 | |
| Biphenyl SCHEMBL11128267 | 0.94 | ALDH1A1 (0.56) | ALDH1A1ACP3PTPN5CA2CA4 | |
| Biphenyl SCHEMBL19244130 | 0.94 | ALDH1A1 (0.56) | ALDH1A1ACP3PTPN5CA2CA4 | |
| Biphenyl SCHEMBL28301372 | 0.94 | ALDH1A1 (0.56) | ALDH1A1ACP3PTPN5CA2CA4 | |
| Biphenyl SCHEMBL28301373 | 0.94 | ALDH1A1 (0.56) | ALDH1A1ACP3PTPN5CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103313604-B | Polymorph in [ 5-amino-1- (2, 6-dichloro-4-trifluoromethylphenyl) -3-carbonitrile-4-trifluoromethylsulfinylpyrazole ] | K.H. Garda (IN) | 2016-03-02 | — | — | CN | disclosed |
| US-9161530-B2 | Method for enhancing efficacy of agrichemical, and agrichemical-containing composition | KAO CORPORATION (JP) | 2015-10-20 | — | — | US | disclosed |
| CN-103209588-B | Method for producing crops | KAO CORP. (JP) | 2015-08-12 | — | — | CN | disclosed |
| CN-102302000-B | Herbicide composition | KAO CORP | 2015-01-07 | — | — | CN | disclosed |
| CN-103313604-A | Polymorph in [ 5-amino-1- (2, 6-dichloro-4-trifluoromethylphenyl) -3-carbonitrile-4-trifluoromethylsulfinylpyrazole ] | GHARDA KEKI HORMUSJI | 2013-09-18 | — | — | CN | disclosed |
| CN-103209588-A | Method for producing crops | KAO CORP | 2013-07-17 | — | — | CN | disclosed |
| US-20120015813-A1 | METHOD FOR ENHANCING EFFICACY OF AGRICHEMICAL, AND AGRICHEMICAL-CONTAINING COMPOSITION | KAO CORPORATION (JP) | 2012-01-19 | — | — | US | disclosed |
| CN-102302000-A | Herbicide composition | KAO CORP | 2012-01-04 | — | — | CN | disclosed |
| CN-101014243-B | Herbicidal composition | KAO CORP | 2011-09-14 | — | — | CN | disclosed |
| CN-101014243-A | Herbicidal composition | KAO CORP (JP) | 2007-08-08 | — | — | CN | disclosed |
| CN-1077768-C | Liquid composition for stabilizing bipyridinium series herbicides | KAO CORP (JP) | 2002-01-16 | — | — | CN | disclosed |
| CN-1073795-C | Agricultural chemical composition | KAO CORP (JP) | 2001-10-31 | — | — | CN | disclosed |
| CN-1067517-C | Composition herbicide | KAO CORP (JP) | 2001-06-27 | — | — | CN | disclosed |
| CN-1180296-A | Pesticide synergist and pesticide composition | KAO CORP (JP) | 1998-04-29 | — | — | CN | disclosed |
| CN-1173110-A | Adjuvant composition for agricutural chemicals and method for enhancing the efficacy of agricultural chemical | KAO CROP (JP) | 1998-02-11 | — | — | CN | disclosed |
| CN-1164815-A | Liquid composition for stabilizing amino acid series herbicides | KAO CORP (JP) | 1997-11-12 | — | — | CN | disclosed |
| CN-1164814-A | Liquid composition for stabilizing bipyridinium series herbicides | KAO CORP (JP) | 1997-11-12 | — | — | CN | disclosed |
| CN-1149239-A | Composition herbicide | KAO CORP (JP) | 1997-05-07 | — | — | CN | disclosed |
| CN-1118567-A | Enhancer composition for agricultural chemicals and agricultural chemical composition | KAO CORP (JP) | 1996-03-13 | — | — | CN | disclosed |
| CN-1111474-A | Agricultural chemical composition | KAO CORP (JP) | 1995-11-15 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015813-A1 | METHOD FOR ENHANCING EFFICACY OF AGRICHEMICAL, AND AGRICHEMICAL-CONTAINING COMPOSITION | GYS2, S100P, AMY1A | ALDH1A1 2482/4885ACP3 315/4885PTPN5 1277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.