Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | GCK | P35557 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828252 | 0.88 | CSNK2A1 (0.35) | NPC1RAB9A | |
| SCHEMBL2829284 | 0.85 | NPC1 (0.41) | NPC1RAB9ASMN1; SMN2ALDH1A1ABCG2 | |
| SCHEMBL5200154 | 0.84 | GRM5 (0.48) | NPC1RAB9ASMN1; SMN2CDK4CDK2 | |
| SCHEMBL2828971 | 0.83 | NPC1 (0.37) | NPC1RAB9ASMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL2826867 | 0.83 | CDK4 (0.45) | NPC1RAB9ASMN1; SMN2CDK4CDK2 | |
| SCHEMBL2827684 | 0.81 | GRM5 (0.48) | NPC1RAB9ATSHRJAK3 | |
| SCHEMBL2831219 | 0.81 | NPC1 (0.37) | NPC1RAB9ASMN1; SMN2ALDH1A1GCK | |
| SCHEMBL2825870 | 0.81 | NPC1 (0.39) | NPC1RAB9ASMN1; SMN2ALDH1A1PDE4B | |
| SCHEMBL2827806 | 0.80 | GRM5 (0.44) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL2829701 | 0.80 | GRM5 (0.48) | NPC1RAB9ASMN1; SMN2CDK4CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |