Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2829284 | 0.91 | NPC1 (0.41) | NPC1RAB9AKDM1ARCOR1SMN1; SMN2 | |
| SCHEMBL5200364 | 0.86 | GRM5 (0.46) | NPC1RAB9AKDM1AMAOBRCOR1 | |
| SCHEMBL2830183 | 0.83 | NPC1 (0.40) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL2827684 | 0.81 | GRM5 (0.48) | NPC1RAB9ANOTUMGRM5JAK3 | |
| SCHEMBL2831219 | 0.81 | NPC1 (0.37) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL2829461 | 0.80 | GRM5 (0.48) | NPC1RAB9AKDM1AMAOBRCOR1 | |
| SCHEMBL2824749 | 0.80 | MET (0.42) | NPC1RAB9AKDM1AMAOBRCOR1 | |
| SCHEMBL2825870 | 0.80 | NPC1 (0.39) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL2827806 | 0.80 | GRM5 (0.44) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL2826482 | 0.78 | NPC1 (0.40) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |