Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 10/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.42 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.42 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.37 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18702831 | 0.84 | CES1 (0.61) | CES1ALDH1A1ALDH2ALDH3A1TGM2 | |
| SCHEMBL14995633 | 0.81 | ALDH1A1 (0.49) | CES1ALDH1A1ALDH2ALDH3A1TGM2 | |
| SCHEMBL695322 | 0.76 | MEN1 (0.50) | CES1ALDH1A1ALDH2ALDH3A1TGM2 | |
| SCHEMBL4555257 | 0.75 | CES1 (0.57) | CES1ALDH1A1ALDH2ALDH3A1TGM2 | |
| SCHEMBL712833 | 0.73 | CES1 (0.69) | CES1ALDH1A1ALDH2ALDH3A1DAO | |
| SCHEMBL29976912 | 0.71 | ALDH1A1 (0.42) | ALDH1A1L3MBTL1NPC1PLA2G1BNFKB1 | |
| SCHEMBL1247409 | 0.69 | TGM2 (0.55) | CES1ALDH1A1TGM2L3MBTL1NPC1 | |
| SCHEMBL30541907 | 0.69 | TGM2 (0.55) | CES1ALDH1A1TGM2L3MBTL1NPC1 | |
| SCHEMBL1171494 | 0.69 | GABRA1 (0.43) | ALDH1A1L3MBTL1NPC1PLA2G1BNFKB1 | |
| SCHEMBL4555733 | 0.68 | CES1 (0.59) | CES1ALDH1A1ALDH2ALDH3A1TGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1915357-B1 | 2-HYDROXY-PROPIONIC ACID DERIVATIVES AND 3-HYDROXY-BENZOFURAN-2-ONE DERIVATIVES WITH AFFINITY FOR THE GABA-B-RECEPTOR | HOFFMANN LA ROCHE (CH) | 2010-09-08 | — | — | EP | disclosed |
| US-7504428-B2 | 2-phenyl-3,3,3-trifluoro-2-hydroxy-propionic acid derivatives | HOFFMAN-LA ROCHE INC. (US) | 2009-03-17 | — | — | US | disclosed |
| US-20080234356-A1 | 2-PHENYL-3,3,3-TRIFLUORO-2-HYDROXY-PROPIONIC ACID DERIVATIVES | MALHERBE PARICHEHR | 2008-09-25 | — | — | US | disclosed |
| US-7396853-B2 | 2-phenyl-3,3,3-trifluoro-2-hydroxy-propionic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-07-08 | — | — | US | disclosed |
| EP-1915357-A1 | 2-HYDROXY-PROPIONIC ACID DERIVATIVES AND 3-HYDROXY-BENZOFURAN-2-ONE DERIVATIVES WITH AFFINITY FOR THE GABA-B-RECEPTOR | F. Hoffmann-Roche AG (CH) | 2008-04-30 | — | — | EP | disclosed |
| WO-2007014843-A1 | 2-HYDROXY-PROPIONIC ACID DERIVATIVES AND 3-HYDROXY-BENZOFURAN-2-ONE DERIVATIVES WITH AFFINITY FOR THE GABA-B-RECEPTOR | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-08 | — | — | WO | disclosed |
| US-20070027204-A1 | 2-phenyl-3,3,3-trifluoro-2-hydroxy-propionic acid derivatives | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2007-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027204-A1 | 2-phenyl-3,3,3-trifluoro-2-hydroxy-propionic acid derivatives | GABRA3, GABRA2, GABRA1 | CES1 778/4885ALDH1A1 225/4885ALDH2 216/4885 |
| US-20080234356-A1 | 2-PHENYL-3,3,3-TRIFLUORO-2-HYDROXY-PROPIONIC ACID DERIVATIVES | GABBR1, GABRA2, GABRA3 | CES1 1615/4885ALDH1A1 270/4885ALDH2 337/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.