Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SCD | O00767 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GRM5 | P41594 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2830868 | 0.83 | MAPT (0.46) | NPC1RAB9AALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL2828553 | 0.78 | PIK3C3 (0.38) | GRM5HPGD | |
| SCHEMBL2825830 | 0.78 | RAB9A (0.44) | NPC1RAB9ASCDALDH1A1SMN1; SMN2 | |
| SCHEMBL2824937 | 0.77 | KDM4E (0.39) | NPC1RAB9ASCDALDH1A1SMN1; SMN2 | |
| SCHEMBL2828836 | 0.77 | NPC1 (0.42) | NPC1RAB9AALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL2824596 | 0.76 | SMARCA2 (0.43) | NPC1RAB9AGRM5CASP3SENP8 | |
| SCHEMBL2830798 | 0.76 | GRM5 (0.44) | NPC1RAB9ASMN1; SMN2GRM5MAPT | |
| SCHEMBL2828434 | 0.76 | MAPT (0.50) | NPC1RAB9AALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL2828498 | 0.76 | GRM5 (0.44) | NPC1RAB9ASCDALDH1A1KMT2A | |
| SCHEMBL2829129 | 0.75 | GRM5 (0.41) | NPC1RAB9ASMN1; SMN2KMT2AGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |