Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.39 |
| ▸ | CTSK | P43235 | 5/20 | 0.39 |
| ▸ | CTSL | P07711 | 4/20 | 0.39 |
| ▸ | CTSB | P07858 | 3/20 | 0.39 |
| ▸ | TACR1 | P25103 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28818066 | 0.86 | DRD2 (0.41) | KMT2AMEN1ALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL28821594 | 0.86 | ELANE (0.38) | SLC6A2SLC6A4SLC6A3CTSKCTSL | |
| SCHEMBL28023815 | 0.85 | CYP17A1 (0.39) | ALDH1A1CYP2C9 | |
| SCHEMBL27935397 | 0.84 | HTR1A (0.39) | SLC6A2SLC6A4SLC6A3KMT2AMEN1 | |
| SCHEMBL28023819 | 0.82 | CYP1A2 (0.40) | OPRM1SLC6A2SLC6A4SLC6A3KMT2A | |
| SCHEMBL28818063 | 0.81 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3TSHRCYP2D6 | |
| SCHEMBL20473183 | 0.80 | SLC6A2 (0.43) | OPRM1SLC6A2SLC6A4SLC6A3CTSK | |
| SCHEMBL28114744 | 0.78 | OPRM1 (0.42) | OPRM1SLC6A2SLC6A4SLC6A3CTSK | |
| SCHEMBL28023208 | 0.77 | OPRM1 (0.31) | OPRM1 | |
| SCHEMBL1574471 | 0.76 | TACR1 (0.44) | OPRM1SLC6A2SLC6A4SLC6A3TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110177786-A | Pyrazolo [1,5-A] pyridine compounds being substituted are as RET kinase inhibitor | 阿雷生物药品公司 | 2019-08-27 | — | — | CN | disclosed |