SCHEMBL28333293

SCHEMBL28333293

c1ccc2nc(-n3cncn3)ncc2c1

nearest known ligand 0.46

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HTR3A P46098 1/20 0.46
HRH4 Q9H3N8 1/20 0.46
EGFR P00533 1/20 0.43
LMNA P02545 1/20 0.41
CYP2A6 P11509 1/20 0.41
HCRTR1 O43613 1/20 0.38
HCRTR2 O43614 1/20 0.38
HCAR2 Q8TDS4 1/20 0.36
PIM1 P11309 1/20 0.35
KDM4E B2RXH2 3/20 0.35
GPR3 P46089 1/20 0.35
PDE10A Q9Y233 4/20 0.34
CYP1A2 P05177 2/20 0.34
ALDH1A1 P00352 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
MAPK10 P53779 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8669666 0.72 ALDH1A1 (0.44) HTR3AHRH4LMNACYP2A6KDM4E
SCHEMBL10772513 0.71 NPC1 (0.45) HTR3AHRH4LMNACYP2A6HCRTR2
SCHEMBL7457811 0.70 CYP11B1 (0.56) HTR3AHRH4EGFRLMNACYP2A6
SCHEMBL8330832 0.68 ADORA2A (0.38) LMNACYP2A6KDM4EPDE10ACYP1A2
SCHEMBL8671760 0.68 TDP1 (0.45) LMNACYP2A6KDM4EPDE10ACYP1A2
SCHEMBL10759266 0.68 CYP2A6 (0.48) LMNACYP2A6PIM1KDM4EPDE10A
SCHEMBL1164441 0.67 LMNA (0.41) LMNACYP2A6PIM1KDM4EPDE10A
SCHEMBL22325535 0.67 CYP2A6 (0.40) LMNACYP2A6KDM4ECYP1A2ALDH1A1
SCHEMBL2898324 0.67 CYP2A6 (0.40) LMNACYP2A6PIM1KDM4EPDE10A
SCHEMBL3625207 0.67 CYP2A6 (0.41) LMNACYP2A6PIM1KDM4ECYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110461151-A Solvent type wood preservative composition KOPPERS PERFORMANCE CHEMICALS INC 2019-11-15 CN disclosed