Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29511352 | 0.82 | GPR119 (0.39) | GPR119USP2SMN1; SMN2NR1H2KDM4E | |
| SCHEMBL15797129 | 0.80 | MAPK1 (0.39) | MEN1KMT2ACHRM2CHRM1CHRM3 | |
| SCHEMBL30867786 | 0.80 | MAPK1 (0.39) | MEN1KMT2ACHRM2CHRM1CHRM3 | |
| SCHEMBL31066400 | 0.80 | MAPK1 (0.39) | MEN1KMT2ACHRM2CHRM1CHRM3 | |
| SCHEMBL23466965 | 0.79 | RORC (0.41) | MEN1KMT2AGPR119NR1H2HSD17B10 | |
| SCHEMBL16080218 | 0.78 | HSD11B1 (0.33) | MEN1KMT2ACHRM2CHRM1CHRM3 | |
| SCHEMBL29481662 | 0.77 | MAPK1 (0.41) | MEN1KMT2ACHRM2CHRM1CHRM3 | |
| SCHEMBL31460381 | 0.76 | CHRM2 (0.42) | CHRM2CHRM1CHRM3HSD11B1USP2 | |
| SCHEMBL19868987 | 0.76 | HSD11B1 (0.40) | MEN1KMT2ACHRM2CHRM1CHRM3 | |
| SCHEMBL24894203 | 0.75 | CTSK (0.40) | MEN1KMT2ACHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109053523-B | Azetidines as MEK inhibitors for the treatment of proliferative diseases | 埃克塞利希斯股份有限公司 | 2022-03-25 | — | — | CN | disclosed |
| CN-110668988-A | Azetidines as MEK inhibitors for the treatment of proliferative diseases | 埃克塞利希斯股份有限公司 | 2020-01-10 | — | — | CN | disclosed |