Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | NPY1R | P25929 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL992990 | 0.85 | — | — | |
| Oxalic Acid SCHEMBL9795096 | 0.83 | ALDH1A1 (0.39) | ALDH1A1GAAMEN1KMT2AUSP2 | |
| Hydrochloric Acid SCHEMBL19926678 | 0.83 | — | — | |
| SCHEMBL28669812 | 0.83 | — | — | |
| Trifluoroacetic Acid SCHEMBL7711992 | 0.81 | NPC1 (0.33) | ALDH1A1LMNAMEN1KMT2APOLB | |
| Trifluoroacetic Acid SCHEMBL10693346 | 0.78 | ANPEP (0.42) | ALDH1A1GAALMNASMN1; SMN2L3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL1289960 | 0.78 | MMP2 (0.35) | ALDH1A1GAALMNAMEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL13519111 | 0.78 | MCL1 (0.38) | ALDH1A1MEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL23569502 | 0.75 | ALDH1A1 (0.58) | ALDH1A1MEN1KMT2APOLBSMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL11288932 | 0.74 | ITGB1 (0.38) | ALDH1A1LMNAMAPTMMP2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109053523-B | Azetidines as MEK inhibitors for the treatment of proliferative diseases | 埃克塞利希斯股份有限公司 | 2022-03-25 | — | — | CN | disclosed |
| CN-110668988-A | Azetidines as MEK inhibitors for the treatment of proliferative diseases | 埃克塞利希斯股份有限公司 | 2020-01-10 | — | — | CN | disclosed |