Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 6/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 6/20 | 0.44 |
| ▸ | PDK3 | Q15120 | 6/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15638317 | 0.84 | NOTUM (0.51) | ACENPC1ALDH1A1NOTUM | |
| SCHEMBL28068692 | 0.83 | ACE (0.47) | ACETSHRPDK1PDK2PDK3 | |
| SCHEMBL20462833 | 0.81 | TSHR (0.62) | ACETSHRPDK1PDK2PDK3 | |
| SCHEMBL29746320 | 0.80 | PDK1 (0.48) | ACETSHRPDK1PDK2PDK3 | |
| SCHEMBL3441713 | 0.79 | ACE (0.47) | ACE | |
| SCHEMBL8018491 | 0.78 | MTNR1A (0.51) | ACETSHRPDK1PDK2PDK3 | |
| SCHEMBL1650576 | 0.78 | PDK1 (0.62) | ACETSHRPDK1PDK2PDK3 | |
| SCHEMBL30018725 | 0.73 | MTNR1A (0.46) | TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL7276961 | 0.72 | ACE (0.64) | ACETSHRNOTUM | |
| SCHEMBL9724439 | 0.72 | ACE (0.64) | ACETSHRNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113382991-A | Aminopyrimidines useful for inhibiting protein tyrosine kinase activity | 深圳市塔吉瑞生物医药有限公司 | 2021-09-10 | — | — | CN | disclosed |
| CN-110818690-B | Aminopyrimidines useful for inhibiting protein tyrosine kinase activity | 深圳市塔吉瑞生物医药有限公司 | 2021-08-10 | — | — | CN | disclosed |
| CN-110818690-A | Aminopyrimidines useful for inhibiting protein tyrosine kinase activity | 深圳市塔吉瑞生物医药有限公司 | 2020-02-21 | — | — | CN | disclosed |
| CN-108602802-B | Aminopyrimidines useful for inhibiting protein tyrosine kinase activity | 深圳市塔吉瑞生物医药有限公司 | 2020-01-21 | — | — | CN | disclosed |