SCHEMBL28354564

SCHEMBL28354564

C=CC(CC(=O)CC(C=C)NC(C)=O)NC(C)=O

nearest known ligand 0.35

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.33
MAPT P10636 1/20 0.33
THRB P10828 1/20 0.33
ALOX15 P16050 1/20 0.33
NFKB1 P19838 1/20 0.33
PTGS2 P35354 1/20 0.33
THPO P40225 1/20 0.33
RECQL P46063 1/20 0.33
BLM P54132 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
ALDH1A1 P00352 2/20 0.32
CRAT P43155 1/20 0.32
TSHR P16473 1/20 0.32
PLA2G2C Q5R387 1/20 0.30
ITGB3 P05106 3/20 0.30
ITGA2B P08514 3/20 0.30
CTRB1 P17538 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11296644 0.80
SCHEMBL11523628 0.77 PLA2G2C (0.39) KDM4EMAPTTHRBALOX15NFKB1
SCHEMBL24629598 0.75 ALDH1A1 (0.35) KDM4EMAPTTHRBALOX15NFKB1
SCHEMBL24126227 0.74 PLA2G2C (0.34) KDM4EMAPTTHRBALOX15NFKB1
SCHEMBL6559575 0.72 PLA2G2C (0.42) MAPTRECQLSMN1; SMN2ALDH1A1TSHR
SCHEMBL5818367 0.72 PLA2G2C (0.46) MAPTALDH1A1PLA2G2C
SCHEMBL13716617 0.70
SCHEMBL7796543 0.69 CTRB1 (0.59) CTRB1
SCHEMBL11685724 0.68 CTSK (0.38) KDM4EMAPTTHRBALOX15NFKB1
SCHEMBL164682 0.67

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108473305-B System and method to detect the source of a molecule, and computer readable medium 北德克萨斯大学 2020-01-03 CN disclosed