Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 5/20 | 0.37 |
| ▸ | RORC | P51449 | 5/20 | 0.36 |
| ▸ | JAK2 | O60674 | 3/20 | 0.35 |
| ▸ | JAK1 | P23458 | 3/20 | 0.35 |
| ▸ | JAK3 | P52333 | 3/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | ACP1 | P24666 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28359066 | 0.80 | TYK2 (0.49) | TYK2RORCJAK2JAK1JAK3 | |
| SCHEMBL29552318 | 0.71 | MAPK6 (0.43) | RORCJAK2JAK1JAK3MAPK7 | |
| SCHEMBL28362626 | 0.68 | JAK1 (0.49) | TYK2RORCJAK2JAK1JAK3 | |
| SCHEMBL29552173 | 0.67 | TYK2 (0.48) | TYK2RORCJAK2JAK1JAK3 | |
| SCHEMBL29922902 | 0.64 | JAK1 (0.41) | TYK2JAK2JAK1JAK3PIM1 | |
| SCHEMBL25268365 | 0.61 | BTK (0.42) | TYK2JAK2JAK1JAK3BTK | |
| SCHEMBL29552977 | 0.60 | CTSC (0.41) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL31108128 | 0.59 | ALDH1A1 (0.39) | MET | |
| SCHEMBL18765045 | 0.59 | SLC40A1 (0.65) | — | |
| SCHEMBL29552080 | 0.58 | MAPT (0.42) | TYK2RORCJAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032484-A1 | PYRIDAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 北京诺诚健华医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |