Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 2/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | MAT2A | P31153 | 12/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28369134 | 0.83 | BIRC5 (0.44) | NOTUMLMNAPLA2G10 | |
| SCHEMBL28885169 | 0.83 | NOTUM (0.47) | TDP2NOTUMMAT2AMEN1KMT2A | |
| SCHEMBL28202823 | 0.82 | ALDH1A1 (0.50) | TDP2NOTUMMAT2AMEN1KMT2A | |
| SCHEMBL28365127 | 0.81 | NOTUM (0.52) | TDP2NOTUMMAT2AMEN1KMT2A | |
| SCHEMBL28369700 | 0.80 | NOTUM (0.50) | TDP2NOTUMMAT2AMEN1LMNA | |
| SCHEMBL28368799 | 0.78 | NOTUM (0.46) | TDP2NOTUMMAT2AMEN1KMT2A | |
| SCHEMBL28365129 | 0.78 | CYP19A1 (0.49) | NOTUMMAT2AMEN1KMT2AL3MBTL1 | |
| SCHEMBL22222295 | 0.76 | TDP2 (0.50) | TDP2MAT2APRMT5MEN1LMNA | |
| SCHEMBL8897533 | 0.73 | PSMB8 (0.38) | MAT2ALMNAL3MBTL1 | |
| SCHEMBL28365593 | 0.72 | NOTUM (0.49) | NOTUMMAT2AMEN1KMT2APLA2G10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107619385-B | Method for synthesizing 2-trifluoromethyl indole by palladium-catalyzed aryl enamine intramolecular amine | 温州大学 | 2020-02-21 | — | — | CN | disclosed |