Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | L3MBTL3 | Q96JM7 | 5/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | TP53BP1 | Q12888 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CBX7 | O95931 | 2/20 | 0.47 |
| ▸ | CDYL2 | Q8N8U2 | 2/20 | 0.47 |
| ▸ | CDYL | Q9Y232 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4378474 | 0.90 | KDM4E (0.61) | L3MBTL1MAPTKDM4EGAAATM | |
| SCHEMBL4380926 | 0.89 | KDM4E (0.60) | L3MBTL1MAPTKDM4EGAAATM | |
| SCHEMBL2833292 | 0.81 | L3MBTL1 (0.58) | L3MBTL1KDM4EGAAL3MBTL3TP53BP1 | |
| SCHEMBL2831262 | 0.78 | NPC1 (0.76) | MAPTKDM4EGAATDP1ACHE | |
| SCHEMBL14218059 | 0.76 | KMT2A (0.67) | L3MBTL1MAPTKDM4EGAAATM | |
| SCHEMBL2852216 | 0.74 | ALDH1A1 (0.49) | L3MBTL1MAPTKDM4ETDP1L3MBTL3 | |
| SCHEMBL4377257 | 0.73 | RAB9A (0.75) | L3MBTL1MAPTKDM4EGAAATM | |
| SCHEMBL2852341 | 0.73 | CYP1A2 (0.52) | L3MBTL1KDM4EL3MBTL3ACHETP53BP1 | |
| SCHEMBL31323039 | 0.72 | SMN1; SMN2 (0.66) | L3MBTL1MAPTKDM4EATMTDP1 | |
| SCHEMBL4377583 | 0.72 | MAPT (0.77) | L3MBTL1MAPTKDM4EGAAATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | claimed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |
| US-7064135-B2 | Substituted piperidines | NOVO NORDISK INC. (DK) | 2006-06-20 | — | — | US | disclosed |