Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | L3MBTL3 | Q96JM7 | 5/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | TP53BP1 | Q12888 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4378626 | 0.91 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1HPGDTSHRKDM4E | |
| SCHEMBL4375723 | 0.90 | TSHR (0.52) | ALDH1A1L3MBTL1HPGDTSHRKDM4E | |
| SCHEMBL14218007 | 0.78 | ALDH1A1 (0.52) | ALDH1A1L3MBTL1HPGDTSHRKDM4E | |
| SCHEMBL2829573 | 0.76 | L3MBTL1 (0.48) | ALDH1A1L3MBTL1HPGDTSHRKDM4E | |
| SCHEMBL4376244 | 0.76 | NPC1 (0.59) | ALDH1A1L3MBTL1HPGDTSHRKDM4E | |
| SCHEMBL2829774 | 0.75 | L3MBTL3 (0.48) | ALDH1A1L3MBTL1HPGDTSHRKDM4E | |
| SCHEMBL4379550 | 0.75 | ALDH1A1 (0.51) | ALDH1A1L3MBTL1HPGDTSHRKDM4E | |
| SCHEMBL2836574 | 0.74 | L3MBTL1 (0.58) | L3MBTL1HPGDTSHRKDM4EMAPT | |
| SCHEMBL3070296 | 0.71 | POLB (0.62) | ALDH1A1L3MBTL1HPGDTSHRKDM4E | |
| SCHEMBL2833292 | 0.70 | L3MBTL1 (0.58) | ALDH1A1L3MBTL1KDM4ELMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | claimed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |
| US-7064135-B2 | Substituted piperidines | NOVO NORDISK INC. (DK) | 2006-06-20 | — | — | US | disclosed |