Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | ATM | Q13315 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ANPEP | P15144 | 1/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.47 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4377257 | 0.84 | RAB9A (0.75) | KMT2ARAB9AMEN1KDM4EMAPT | |
| SCHEMBL2377627 | 0.80 | KMT2A (0.77) | KMT2ARAB9AMEN1KDM4EHPGD | |
| SCHEMBL4378474 | 0.79 | KDM4E (0.61) | KMT2ARAB9AKDM4EMAPTL3MBTL1 | |
| SCHEMBL16578041 | 0.78 | HSD11B1 (0.69) | KMT2AMEN1KDM4ELMNAALDH1A1 | |
| SCHEMBL4380926 | 0.78 | KDM4E (0.60) | KMT2ARAB9AKDM4EMAPTL3MBTL1 | |
| SCHEMBL4377583 | 0.78 | MAPT (0.77) | KDM4EMAPTL3MBTL1GAAATM | |
| SCHEMBL4379070 | 0.77 | KDM4E (0.76) | KMT2ARAB9AMEN1KDM4EMAPT | |
| SCHEMBL2836574 | 0.76 | L3MBTL1 (0.58) | KMT2ARAB9AKDM4EMAPTL3MBTL1 | |
| SCHEMBL9950430 | 0.73 | PKM (0.70) | KMT2ARAB9AMEN1KDM4EMAPT | |
| SCHEMBL14218007 | 0.73 | ALDH1A1 (0.52) | KMT2ARAB9AMEN1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080113968-A1 | Substituted piperazines and diazepanes | NOVO NORDISK A/S (DK) | 2008-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113968-A1 | Substituted piperazines and diazepanes | HRH3, HRH4, HRH1 | KMT2A 295/4885RAB9A 3209/4885MEN1 2570/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.