Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 2/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5341560 | 0.76 | GPR119 (0.36) | GPR119KDM1ANR1H2BCHEABCB1 | |
| SCHEMBL5847936 | 0.73 | GPR119 (0.33) | GPR119KDM1ABCHEABCB1CHRM2 | |
| SCHEMBL8988562 | 0.68 | KLK7 (0.34) | KLK7GPR119NR1H2BCHEKLK5 | |
| SCHEMBL2688973 | 0.66 | GPR119 (0.36) | GPR119NR1H2CHRM2CHRM1CHRM3 | |
| SCHEMBL4670424 | 0.66 | GPR119 (0.33) | KLK7GPR119KDM1ANR1H2BCHE | |
| SCHEMBL24124278 | 0.66 | KLK7 (0.40) | KLK7GPR119BCHECHRM2CHRM1 | |
| SCHEMBL22336304 | 0.66 | GPR119 (0.37) | GPR119NR1H2CHRM2CHRM1CHRM3 | |
| SCHEMBL1258538 | 0.65 | GPR119 (0.32) | GPR119KDM1ABCHEABCB1 | |
| SCHEMBL2809749 | 0.65 | BCHE (0.33) | KLK7GPR119KDM1ABCHEKDM4E | |
| SCHEMBL34473806 | 0.65 | KLK7 (0.36) | KLK7NR1H2BCHECHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8932842-B2 | Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition | NORTHWESTERN UNIVERSITY (US) | 2015-01-13 | — | — | US | disclosed |
| US-20130040359-A1 | Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition | NORTHWESTERN UNIVERSITY (US) | 2013-02-14 | — | — | US | disclosed |
| US-8278084-B2 | Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition | NORTHWESTERN UNIVERSITY (US) | 2012-10-02 | — | — | US | disclosed |
| WO-2010093787-A2 | AMINOPYRIDINE DIMER COMPOUNDS, COMPOSITIONS AND RELATED METHODS FOR NEURONAL NITRIC OXIDE SYNTHASE INHIBITION | NORTHWESTERN UNIVERSITY (US) | 2010-08-19 | — | — | WO | disclosed |
| US-20100203613-A1 | Aminopyridine Dimer Compounds, Compositions and Related Methods for Neuronal Nitric Oxide Synthase Inhibition | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130040359-A1 | Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition | NOS2, NOS1, NOS3 | KLK7 4808/4885GPR119 2304/4885KDM1A 1247/4885 |
| US-20100203613-A1 | Aminopyridine Dimer Compounds, Compositions and Related Methods for Neuronal Nitric Oxide Synthase Inhibition | NOS2, NOS1, NOS3 | KLK7 4808/4885GPR119 2304/4885KDM1A 1247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.