Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.32 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.31 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2835554 | 0.87 | ALDH1A1 (0.33) | SLC6A4SLC6A2SLC6A3OPRK1OPRM1 | |
| SCHEMBL2842973 | 0.80 | TPH1 (0.34) | SLC6A4SLC6A2SLC6A3MAPK1OPRK1 | |
| SCHEMBL2835996 | 0.76 | SLC6A2 (0.35) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL2844559 | 0.73 | OPRD1 (0.37) | SLC6A4SLC6A2SLC6A3ALDH1A1HPGD | |
| SCHEMBL2840993 | 0.72 | OPRD1 (0.36) | OPRK1OPRM1KCNH2UTS2ROPRD1 | |
| SCHEMBL2840919 | 0.70 | UTS2R (0.36) | SLC6A4SLC6A2SLC6A3OPRK1OPRM1 | |
| Hydrochloric Acid SCHEMBL2840295 | 0.69 | UTS2R (0.35) | SLC6A4SLC6A2SLC6A3OPRK1OPRM1 | |
| Hydrochloric Acid SCHEMBL2839679 | 0.69 | OPRK1 (0.42) | OPRK1KCNH2UTS2RHTR4 | |
| Hydrochloric Acid SCHEMBL2836634 | 0.67 | OPRK1 (0.33) | OPRK1OPRM1KCNH2UTS2ROPRD1 | |
| SCHEMBL2839392 | 0.66 | ALDH1A1 (0.34) | SLC6A4SLC6A2SLC6A3OPRK1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8217031-B2 | Heteroaryl derivatives | NIPPON SHINYAKU CO., LTD. (JP) | 2012-07-10 | — | — | US | disclosed |
| US-20100048537-A1 | HETEROARYL DERIVATIVES | NIPPON SHINYAKU CO., LTD. (JP) | 2010-02-25 | — | — | US | disclosed |
| EP-2141168-A1 | HETEROARYL DERIVATIVES | Nippon Shinyaku Co., Ltd. (JP) | 2010-01-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048537-A1 | HETEROARYL DERIVATIVES | OPRD1, OPRM1, OPRK1 | SLC6A4 185/4885SLC6A2 196/4885SLC6A3 118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.