Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.45 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.45 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.43 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.39 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | FAP | Q12884 | 1/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28475071 | 0.85 | CACNA1B (0.43) | DPP4DPP7DPP8HSD11B1MGLL | |
| SCHEMBL27144128 | 0.85 | CACNA1B (0.43) | DPP4DPP7DPP8HSD11B1MGLL | |
| SCHEMBL4236045 | 0.83 | MMP13 (0.51) | DPP4 | |
| SCHEMBL15536288 | 0.83 | FPR2 (0.49) | DPP4DPP7MGLLCACNA2D1CACNA1B | |
| SCHEMBL23212032 | 0.80 | TEAD1 (0.50) | DPP4DPP7DPP8TEAD1GAA | |
| SCHEMBL28162309 | 0.80 | RPS6KB1 (0.53) | DPP4DPP7DPP8TEAD1GAA | |
| SCHEMBL14638795 | 0.72 | HSD11B1 (0.71) | HSD11B1GAATDP1MGLLNOTUM | |
| SCHEMBL21381906 | 0.72 | GAA (0.48) | DPP4DPP7TEAD1HSD11B1GAA | |
| SCHEMBL2636716 | 0.72 | LIPE (0.52) | HSD11B1GAATDP1NOTUM | |
| SCHEMBL17942511 | 0.72 | ADAMTS7 (0.45) | HSD11B1GAATDP1CACNA1BNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106946796-B | Aminopyrimidine derivatives useful as modulators of kinase activity | 默克专利有限公司 | 2020-05-08 | — | — | CN | disclosed |