SCHEMBL28391493

SCHEMBL28391493

COC(=O)c1c2ccccc2c(-c2ccccc2)c2ccccc12

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.60
LMNA P02545 4/20 0.58
ALDH1A1 P00352 2/20 0.53
RAB9A P51151 1/20 0.53
MAPK1 P28482 1/20 0.51
TP53 P04637 2/20 0.50
MAPK8 P45983 1/20 0.50
AR P10275 1/20 0.50
PLA2G2A P14555 1/20 0.49
HTT P42858 1/20 0.49
TSHR P16473 1/20 0.48
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
HPGD P15428 1/20 0.47
PRKCZ Q05513 1/20 0.47
PTGS1 P23219 1/20 0.47
NR4A2 P43354 2/20 0.47
CA12 O43570 1/20 0.47
CA1 P00915 1/20 0.47
CA2 P00918 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL70573 0.86 CA12 (0.60) SMN1; SMN2LMNAALDH1A1MAPK1TSHR
SCHEMBL3194807 0.82 MEN1 (0.60) SMN1; SMN2LMNAALDH1A1MAPK1HTT
SCHEMBL11227892 0.82 LMNA (0.64) SMN1; SMN2LMNAALDH1A1RAB9AMAPK1
SCHEMBL11786743 0.80 CA12 (0.58) SMN1; SMN2LMNAALDH1A1MAPK1TSHR
SCHEMBL29464062 0.79 TSHR (0.61) SMN1; SMN2LMNAALDH1A1RAB9AMAPK1
SCHEMBL4446092 0.79 LMNA (0.60) SMN1; SMN2LMNAALDH1A1RAB9AMAPK1
SCHEMBL75947 0.78 SMN1; SMN2 (0.47) SMN1; SMN2LMNAALDH1A1MAPK8PLA2G2A
SCHEMBL29262209 0.78 LMNA (0.55) LMNAALDH1A1HTTTSHRMEN1
SCHEMBL28032836 0.77 MEN1 (0.63) SMN1; SMN2LMNAALDH1A1MAPK1HTT
SCHEMBL28051400 0.77 NR4A2 (0.50) SMN1; SMN2LMNAALDH1A1MAPK1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111039962-B Nitrogen-containing compound, application thereof and organic electroluminescent device using nitrogen-containing compound 陕西莱特光电材料股份有限公司 2020-11-27 CN disclosed
CN-111039962-A Nitrogen-containing compound, application thereof and organic electroluminescent device using nitrogen-containing compound 陕西莱特光电材料股份有限公司 2020-04-21 CN disclosed