Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 9/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10078688 | 0.89 | SLC6A4 (0.39) | SLC6A4HTR6KDM1ASYKHTR2C | |
| Hydrochloric Acid SCHEMBL2840338 | 0.88 | SLC6A4 (0.38) | SLC6A4HTR6KDM1ASYKHTR2C | |
| SCHEMBL2840814 | 0.73 | SLC6A2 (0.33) | SLC6A4HTR2C | |
| SCHEMBL16595430 | 0.67 | SYK (0.54) | SLC6A4HTR6KDM1ASYKHTR2C | |
| SCHEMBL2845301 | 0.64 | HRH3 (0.36) | SLC6A4 | |
| SCHEMBL10078734 | 0.62 | HTR6 (0.32) | HTR6 | |
| Hydrochloric Acid SCHEMBL2839303 | 0.62 | HTR2C (0.33) | SLC6A4HTR2C | |
| SCHEMBL21381618 | 0.61 | KDM1A (0.43) | SLC6A4KDM1A | |
| SCHEMBL29427047 | 0.60 | S1PR4 (0.44) | SLC6A4KDM1AHTR2C | |
| SCHEMBL2273425 | 0.60 | S1PR4 (0.44) | SLC6A4KDM1AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8217031-B2 | Heteroaryl derivatives | NIPPON SHINYAKU CO., LTD. (JP) | 2012-07-10 | — | — | US | disclosed |
| US-20100048537-A1 | HETEROARYL DERIVATIVES | NIPPON SHINYAKU CO., LTD. (JP) | 2010-02-25 | — | — | US | disclosed |
| EP-2141168-A1 | HETEROARYL DERIVATIVES | Nippon Shinyaku Co., Ltd. (JP) | 2010-01-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048537-A1 | HETEROARYL DERIVATIVES | OPRD1, OPRM1, OPRK1 | SLC6A4 185/4885HTR6 51/4885KDM1A 1447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.