Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHBG | P04278 | 1/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.69 |
| ▸ | GAA | P10253 | 10/20 | 0.69 |
| ▸ | POLB | P06746 | 2/20 | 0.69 |
| ▸ | HTT | P42858 | 2/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.69 |
| ▸ | JAK2 | O60674 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | PKM | P14618 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | MPI | P34949 | 1/20 | 0.69 |
| ▸ | BLM | P54132 | 1/20 | 0.69 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.69 |
| ▸ | GLA | P06280 | 8/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.64 |
| ▸ | HPGD | P15428 | 6/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.64 |
| ▸ | CASP1 | P29466 | 5/20 | 0.59 |
| ▸ | CASP7 | P55210 | 5/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14317878 | 0.88 | SHBG (0.73) | SHBGKDM4EGAAPOLBHTT | |
| SCHEMBL2839705 | 0.82 | KDM4E (1.00) | SHBGKDM4EGAAPOLBHTT | |
| SCHEMBL29528063 | 0.71 | SHBG (0.67) | SHBGKDM4EGAAPOLBHTT | |
| SCHEMBL19236367 | 0.70 | KDM4E (0.79) | SHBGKDM4EGAAPOLBHTT | |
| SCHEMBL7797770 | 0.70 | KDM4E (0.74) | SHBGKDM4EGAAPOLBHTT | |
| SCHEMBL14924903 | 0.70 | KDM4E (0.65) | SHBGKDM4EGAAPOLBHTT | |
| SCHEMBL971942 | 0.69 | KDM4E (1.00) | SHBGKDM4EGAAPOLBHTT | |
| SCHEMBL14924883 | 0.69 | KDM4E (0.48) | SHBGKDM4EGAAPOLBHTT | |
| SCHEMBL11216726 | 0.69 | KDM4E (0.60) | SHBGKDM4EGAAPOLBHTT | |
| SCHEMBL11056055 | 0.68 | KDM4E (0.59) | SHBGKDM4EGAAPOLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9334256-B2 | Agents and methods for treating ischemic and other diseases | NONO INC. (CA) | 2016-05-10 | — | — | US | disclosed |
| US-20140221423-A1 | Agents And Methods For Treating Ischemic And Other Diseases | NONO INC. (CA) | 2014-08-07 | — | — | US | disclosed |
| US-20140221423-A1 | Agents And Methods For Treating Ischemic And Other Diseases | NONO INC. (CA) | 2014-08-07 | — | — | US | disclosed |
| WO-2012174488-A2 | AGENTS AND METHODS FOR TREATING ISCHEMIC AND OTHER DISEASES | NONO, INC. (CA) | 2012-12-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221423-A1 | Agents And Methods For Treating Ischemic And Other Diseases | TRPM7, TRPM8, TRPM5 | SHBG 3305/4885KDM4E 4656/4885GAA 970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.