Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 9/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | CTRC | Q99895 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6027499 | 0.80 | CTRC (0.43) | KMOKMT2ACYP3A4CTRCSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11781329 | 0.79 | KMT2A (0.72) | KMOKMT2ACYP3A4FAAHSMN1; SMN2 | |
| SCHEMBL18604297 | 0.75 | MAPT (0.54) | CYP3A4ALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL11781344 | 0.73 | KMT2A (0.56) | KMOKMT2ACYP3A4FAAHALDH1A1 | |
| Hydrochloric Acid SCHEMBL11790707 | 0.73 | CYP1A2 (0.49) | KMOKMT2ACYP3A4FAAHSMN1; SMN2 | |
| SCHEMBL6027661 | 0.73 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL11786073 | 0.71 | KMO (0.44) | KMOKMT2ACYP3A4MAP4K4FAAH | |
| SCHEMBL14742295 | 0.70 | KMO (1.00) | KMO | |
| SCHEMBL20137308 | 0.70 | KMO (0.63) | KMOMAP4K4FAAHSMN1; SMN2 | |
| SCHEMBL3646180 | 0.69 | CYP3A4 (0.65) | KMT2ACYP3A4ALDH1A1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2251324-A1 | HETEROARYL-ALKYLCARBAMATE COMPOUNDS AND THEIR USE AS INHIBITORS OF THE FAAH ENZYME | Sanofi-Aventis (FR) | 2010-11-17 | — | — | EP | disclosed |
| EP-1720829-A1 | DERIVATIVES OF HETEROARYL-ALKYLCARBAMATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS | Sanofi-Aventis (FR) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005090292-A1 | DERIVATIVES OF HETEROARYL-ALKYLCARBAMATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS | SANOFI-AVENTIS (FR) | 2005-09-29 | — | — | WO | disclosed |