SCHEMBL2840217

SCHEMBL2840217

c1ccc(Cn2ccnc2-c2ccncc2)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LIMK2 P53671 1/20 0.58
HSD17B10 Q99714 1/20 0.57
BRD4 O60885 2/20 0.56
HTR6 P50406 1/20 0.55
P2RX7 Q99572 1/20 0.53
ESR1 P03372 1/20 0.49
KCNH2 Q12809 1/20 0.48
DYRK1A Q13627 1/20 0.48
GRK2 P25098 1/20 0.46
CCNC P24863 1/20 0.46
CDK8 P49336 1/20 0.46
KDM4E B2RXH2 1/20 0.46
ALDH1A1 P00352 2/20 0.44
MEN1 O00255 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2C9 P11712 1/20 0.44
ALOX12 P18054 1/20 0.44
CYP2C19 P33261 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17621 0.91 HSD17B10 (0.62) LIMK2HSD17B10BRD4ESR1ALDH1A1
Hydrochloric Acid SCHEMBL233781 0.90 HSD17B10 (0.60) LIMK2HSD17B10BRD4ESR1KDM4E
Fluoride SCHEMBL10339918 0.90 HSD17B10 (0.60) LIMK2HSD17B10BRD4ESR1ALDH1A1
Iodide SCHEMBL28519464 0.90 HSD17B10 (0.60) LIMK2HSD17B10BRD4ESR1ALDH1A1
Bromide SCHEMBL811908 0.90 HSD17B10 (0.60) LIMK2HSD17B10BRD4ESR1ALDH1A1
SCHEMBL5981532 0.88 LIMK2 (0.63) LIMK2HSD17B10BRD4HTR6ESR1
Fluoride Ion SCHEMBL10906965 0.88 LIMK2 (0.59) LIMK2HSD17B10BRD4ESR1ALDH1A1
Fluoride SCHEMBL10906966 0.88 LIMK2 (0.59) LIMK2HSD17B10BRD4ESR1ALDH1A1
Bromide SCHEMBL811907 0.88 LIMK2 (0.59) LIMK2HSD17B10BRD4ESR1ALDH1A1
SCHEMBL10906967 0.85 LIMK2 (0.56) LIMK2HSD17B10BRD4ESR1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2350059-B1 MULTIHETEROARYL COMPOUNDS AS INHIBITORS OF H-PGDS AND THEIR USE FOR TREATING PROSTAGLANDIN D2 MEDIATED DISEASES CAYMAN CHEM CO (US) 2016-03-23 EP disclosed
US-9126973-B2 Multiheteroaryl compounds as inhibitors of H-PGDS and their use for treating prostaglandin D2 mediated diseases CAYMAN CHEMICAL COMPANY, INCORPORATED (US) 2015-09-08 US disclosed
US-20150099748-A1 MULTIHETEROARYL COMPOUNDS AS INHIBITORS OF H-PGDS AND THEIR USE FOR TREATING PROSTAGLANDIN D2 MEDIATED DISEASES CAYMAN CHEMICAL COMPANY, INCORPORATED 2015-04-09 US disclosed
US-8536185-B2 Multiheteroaryl compounds as inhibitors of H-PGDS and their use for treating prostaglandin D2 mediated diseases CAYMAN CHEMICAL COMPANY, INCORPORATED (US) 2013-09-17 US disclosed
US-8450326-B2 2013-05-28 US disclosed
US-20130079375-A1 MULTIHETEROARYL COMPOUNDS AS INHIBITORS OF H-PGDS AND THEIR USE FOR TREATING PROSTAGLANDIN D2 MEDIATED DISEASES CAYMAN CHEMICAL COMPANY, INCORPORATED (US) 2013-03-28 US disclosed
US-20100075990-A1 MULTIHETEROARYL COMPOUNDS AS INHIBITORS OF H-PGDS AND THEIR USE FOR TREATING PROSTAGLANDIN D2 MEDIATED DISEASES CAYMAN CHEMICAL COMPANY (US) 2010-03-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100075990-A1 MULTIHETEROARYL COMPOUNDS AS INHIBITORS OF H-PGDS AND THEIR USE FOR TREATING PROSTAGLANDIN D2 MEDIATED DISEASES HPGDS, PTGIS, PTGES LIMK2 2892/4885HSD17B10 328/4885BRD4 1082/4885
US-20130079375-A1 MULTIHETEROARYL COMPOUNDS AS INHIBITORS OF H-PGDS AND THEIR USE FOR TREATING PROSTAGLANDIN D2 MEDIATED DISEASES HPGDS, PTGIS, PTGES LIMK2 2892/4885HSD17B10 328/4885BRD4 1082/4885
US-20150099748-A1 MULTIHETEROARYL COMPOUNDS AS INHIBITORS OF H-PGDS AND THEIR USE FOR TREATING PROSTAGLANDIN D2 MEDIATED DISEASES HPGDS, PTGIS, PTGES LIMK2 2892/4885HSD17B10 328/4885BRD4 1082/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.