Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 11/20 | 0.50 |
| ▸ | EPAS1 | Q99814 | 10/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | COXFA4 | O00483 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28417969 | 0.86 | ODC1 (0.45) | HIF1AEPAS1ALDH1A1HPGDKDM4E | |
| SCHEMBL9685221 | 0.80 | CA12 (0.56) | HIF1AEPAS1ALDH1A1HPGDKDM4E | |
| SCHEMBL2012004 | 0.79 | HIF1A (0.46) | HIF1AEPAS1ALDH1A1HPGDKDM4E | |
| SCHEMBL3049240 | 0.77 | ALDH1A1 (0.46) | HIF1AEPAS1ALDH1A1HPGDKDM4E | |
| SCHEMBL7738844 | 0.77 | HIF1A (0.58) | HIF1AEPAS1ALDH1A1HPGDKDM4E | |
| SCHEMBL14178660 | 0.76 | HIF1A (0.63) | HIF1AEPAS1 | |
| SCHEMBL14930293 | 0.76 | HIF1A (0.61) | HIF1AEPAS1 | |
| SCHEMBL12155510 | 0.75 | ALDH1A1 (0.45) | HIF1AEPAS1ALDH1A1KDM4EMAPT | |
| SCHEMBL8723354 | 0.75 | XDH (0.68) | HIF1AEPAS1ALDH1A1HPGDKDM4E | |
| SCHEMBL6024450 | 0.75 | HTR2C (0.54) | HIF1AEPAS1ALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117466803-A | Compounds, salts thereof and methods for treating diseases | 阿卡蒂亚药品公司 | 2024-01-30 | — | — | CN | disclosed |
| CN-111132976-B | Compounds, salts thereof and methods for treating diseases | 阿卡蒂亚药品公司 | 2023-08-22 | — | — | CN | disclosed |
| CN-111132976-A | Compounds, salts thereof and methods for treating diseases | 阿卡蒂亚药品公司 | 2020-05-08 | — | — | CN | disclosed |