Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 11/20 | 0.45 |
| ▸ | EPAS1 | Q99814 | 11/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7738844 | 0.81 | HIF1A (0.58) | ALDH1A1HPGDKDM4ENPC1CA12 | |
| SCHEMBL9475843 | 0.79 | ALDH1A1 (0.45) | ALDH1A1HPGDKDM4ENPC1CA12 | |
| SCHEMBL2012004 | 0.79 | HIF1A (0.46) | ALDH1A1HPGDKDM4ENPC1CA12 | |
| SCHEMBL6024450 | 0.79 | HTR2C (0.54) | ALDH1A1HPGDKDM4ENPC1CA12 | |
| SCHEMBL8723354 | 0.79 | XDH (0.68) | ALDH1A1HPGDKDM4ENPC1CA12 | |
| SCHEMBL482227 | 0.79 | NPSR1 (0.49) | ALDH1A1HPGDKDM4ENPC1CA12 | |
| SCHEMBL9219622 | 0.79 | HTR2C (0.54) | ALDH1A1HPGDKDM4ENPC1CA12 | |
| SCHEMBL9582367 | 0.77 | HIF1A (0.45) | ALDH1A1HPGDKDM4ENPC1CA12 | |
| SCHEMBL9581577 | 0.77 | ALDH1A1 (0.43) | ALDH1A1HPGDKDM4ENPC1CA12 | |
| SCHEMBL5868243 | 0.77 | HIF1A (0.54) | ALDH1A1HPGDKDM4ENPC1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142493-B1 | ISO CA-4 AND ANALOGUES THEREOF AS POTENT CYTOTOXIC AGENTS INHIBITING TUBULINE POLYMERISATION | CENTRE NAT RECH SCIENT (FR) | 2019-03-27 | — | — | EP | disclosed |
| US-8273768-B2 | Iso CA-4 and analogues thereof as potent cytotoxic agents inhibiting tubuline polymerization | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2012-09-25 | — | — | US | disclosed |
| US-20100129471-A1 | ISO CA-4 AND ANALOGUES THEREOF AS POTENT CYTOTOXIC AGENTS INHIBITING TUBULINE POLYMERIZATION | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) | 2010-05-27 | — | — | US | disclosed |
| EP-0764162-A1 | CYCLOBUT-3-ENE-1,2-DIONE DERIVATIVES AS SMOOTH MUSCLE RELAXANTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-03-26 | — | — | EP | disclosed |
| US-5612323-A | ANTIISCHEMIC | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-03-18 | — | — | US | disclosed |
| EP-0401010-B1 | Pyranyl cyanoguanidine derivatives | SQUIBB & SONS INC (US) | 1996-08-21 | — | — | EP | disclosed |
| US-5500442-A | Cyclobut-3-ene-1,2-dione derivatives as smooth muscle relaxants | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-03-19 | — | — | US | disclosed |
| WO-1995034556-A1 | CYCLOBUT-3-ENE-1,2-DIONE DERIVATIVES AS SMOOTH MUSCLE RELAXANTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-12-21 | — | — | WO | disclosed |
| US-5140031-A | Pyranyl cyanoguanidine derivatives | E. R. SQUIBB & SONS, INC. (US) | 1992-08-18 | — | — | US | disclosed |
| EP-0401010-A2 | Pyranyl cyanoguanidine derivatives | E.R. Squibb & Sons, Inc. (US) | 1990-12-05 | — | — | EP | disclosed |
| WO-1990012011-A1 | NOVEL ANTIHYPERTENSIVE BENZOPYRAN DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-10-18 | — | — | WO | disclosed |
| US-4908378-A | Benzopyran derivatives and antihypertensive use thereof | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100129471-A1 | ISO CA-4 AND ANALOGUES THEREOF AS POTENT CYTOTOXIC AGENTS INHIBITING TUBULINE POLYMERIZATION | TUBB4A, TUBA4A, TUBB4B | ALDH1A1 2264/4885HPGD 3936/4885KDM4E 1268/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.