Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.42 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | MMP14 | P50281 | 2/20 | 0.42 |
| ▸ | MMP7 | P09237 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20508397 | 0.78 | MMP2 (0.33) | MMP2MMP9MMP14MMP7CA12 | |
| SCHEMBL28823727 | 0.78 | NFE2L2 (0.44) | MMP2MMP9MMP14MMP7CHRNB2 | |
| SCHEMBL18711221 | 0.78 | TRPV4 (0.48) | MRGPRX4TRPV4CHRNB2CHRNA4PTGS1 | |
| SCHEMBL28406146 | 0.76 | LOXL2 (0.42) | MMP2MMP9MMP14MMP7PTGS1 | |
| SCHEMBL27781618 | 0.76 | KMT2A (0.44) | MMP2MMP9MMP14MMP7CHRNB2 | |
| SCHEMBL27716170 | 0.75 | MAPT (0.46) | CHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL3713538 | 0.75 | CHRNB2 (0.39) | MMP2MMP9MMP14MMP7CHRNB2 | |
| SCHEMBL15453567 | 0.74 | CA2 (0.61) | MMP2MMP9MMP14MMP7CA12 | |
| SCHEMBL929327 | 0.73 | TRPV4 (0.52) | MRGPRX4TRPV4CHRNB2CHRNA4PTGS1 | |
| SCHEMBL27787685 | 0.73 | MRGPRX4 (0.47) | MRGPRX4TRPV4CHRNB2CHRNA4SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114007610-A | Substituted heteroaromatic pyrazolopyridines and their use as modulators of the GLUN2B receptor | 詹森药业有限公司 | 2022-02-01 | — | — | CN | disclosed |