Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | KCNB1 | Q14721 | 1/20 | 0.61 |
| ▸ | KCNB2 | Q92953 | 1/20 | 0.61 |
| ▸ | PHGDH | O43175 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28411034 | 0.91 | LMNA (0.61) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL27656657 | 0.85 | LMNA (0.64) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL27656560 | 0.85 | LMNA (0.64) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL28406386 | 0.85 | ALDH1A1 (0.49) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL31546660 | 0.84 | LMNA (0.63) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL28408448 | 0.83 | ALDH1A1 (0.52) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL28890744 | 0.82 | ALDH1A1 (0.51) | MEN1KMT2AALDH1A1 | |
| SCHEMBL31546635 | 0.82 | ALDH1A1 (0.64) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL28406352 | 0.81 | MAPT (0.48) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL28257377 | 0.80 | KCNB1 (0.52) | LMNAMAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108929263-B | Arylamide Kv2.1 inhibitor and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2022-07-22 | — | — | CN | disclosed |
| CN-111108092-A | Arylamide Kv2.1 inhibitor and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2020-05-05 | — | — | CN | disclosed |
| CN-108929263-A | Aryl amide Kv2.1 inhibitor and preparation method thereof, pharmaceutical composition and purposes | 中国医学科学院药物研究所 | 2018-12-04 | — | — | CN | disclosed |