Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7258863 | 0.88 | ADRB1 (0.44) | ADRB1SIRT6EGFRALDH1A1KCNJ1 | |
| SCHEMBL7230204 | 0.83 | ADRB1 (0.44) | ADRB1SIRT6ALDH1A1KCNJ1KCNH2 | |
| SCHEMBL30165832 | 0.77 | ALDH1A1 (0.50) | ADRB1SIRT6ALDH1A1MAPTLMNA | |
| SCHEMBL8127953 | 0.77 | ADRB1 (0.53) | ADRB1SIRT6ALDH1A1KCNJ1KCNH2 | |
| SCHEMBL1184197 | 0.75 | ALDH1A1 (0.43) | ALDH1A1MAPTTDP1KDM4E | |
| SCHEMBL27544020 | 0.75 | ADRB1 (0.47) | ADRB1SIRT6ALDH1A1KCNJ1KCNH2 | |
| SCHEMBL522461 | 0.74 | ADRB1 (0.43) | ADRB1SIRT6ALDH1A1KCNJ1KCNH2 | |
| SCHEMBL27758968 | 0.71 | ADRB1 (0.43) | ADRB1SIRT6ALDH1A1KCNJ1KCNH2 | |
| Hydrochloric Acid SCHEMBL19468123 | 0.71 | KCNJ1 (0.44) | ADRB1SIRT6ALDH1A1KCNJ1KCNH2 | |
| SCHEMBL10625782 | 0.69 | ALDH1A1 (0.40) | ADRB1SIRT6ALDH1A1KCNJ1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111138358-B | USP8 inhibitor and preparation method and application thereof | 中国药科大学 | 2023-04-18 | — | — | CN | disclosed |
| CN-111138358-A | USP8 inhibitor and preparation method and application thereof | 中国药科大学 | 2020-05-12 | — | — | CN | disclosed |