Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | CTSV | O60911 | 3/20 | 0.38 |
| ▸ | CTSL | P07711 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28423303 | 0.90 | CTSV (0.42) | LMNAALDH1A1POLBHTTSMN1; SMN2 | |
| SCHEMBL28415410 | 0.85 | CTSV (0.38) | LMNAHPGDALDH1A1POLBHTT | |
| SCHEMBL28416297 | 0.83 | LMNA (0.47) | LMNAHPGDALDH1A1POLBHTT | |
| SCHEMBL29858779 | 0.80 | LMNA (0.44) | LMNAHPGDALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL5962774 | 0.72 | PKM (0.56) | LMNAHPGDALDH1A1POLBHTT | |
| SCHEMBL16342378 | 0.72 | LMNA (0.48) | LMNAHPGDALDH1A1POLBHTT | |
| SCHEMBL30524610 | 0.72 | LMNA (0.49) | LMNAHPGDALDH1A1POLBHTT | |
| SCHEMBL16055036 | 0.72 | NPC1 (0.47) | LMNAHPGDALDH1A1SMN1; SMN2ALOX5AP | |
| SCHEMBL24983669 | 0.71 | LMNA (0.56) | LMNAHPGDALDH1A1CTSVCTSL | |
| SCHEMBL30141003 | 0.71 | LMNA (0.56) | LMNAHPGDALDH1A1CTSVCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111196816-B | Seven-membered ring compound and application thereof in preventing and treating diabetes and metabolic syndrome | 中国科学院上海药物研究所 | 2022-11-04 | — | — | CN | disclosed |
| CN-111196816-A | Seven-membered ring compound and application thereof in preventing and treating diabetes and metabolic syndrome | 中国科学院上海药物研究所 | 2020-05-26 | — | — | CN | disclosed |