Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 4/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | ERN1 | O75460 | 1/20 | 0.44 |
| ▸ | PTPRC | P08575 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | FPR1 | P21462 | 2/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TNFSF11 | O14788 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | GGT1 | P19440 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28415328 | 0.83 | BACE1 (0.48) | BACE1KDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL7037049 | 0.81 | GAPDH (0.52) | BACE1PTPRCPTPN1ALDH1A1TDP1 | |
| SCHEMBL8584051 | 0.79 | BACE1 (0.57) | BACE1PTPRCPTPN1PTGER4HSD17B10 | |
| SCHEMBL28414813 | 0.77 | EGLN1 (0.47) | ADORA3ERN1PTPRCPTPN1KDM4E | |
| SCHEMBL28418982 | 0.76 | ADORA3 (0.46) | ADORA3ERN1PTPRCPTPN1TSHR | |
| SCHEMBL16236644 | 0.73 | KDM4E (0.53) | BACE1FPR1TSHRKDM4EHSD17B10 | |
| SCHEMBL10765006 | 0.73 | KMT2A (0.44) | BACE1KDM4ETNFSF11ALDH1A1HPGD | |
| SCHEMBL3453107 | 0.73 | LMNA (0.50) | BACE1KDM4EHSD17B10ALDH1A1TDP1 | |
| SCHEMBL14710190 | 0.73 | LMNA (0.46) | BACE1KDM4EHSD17B10ALDH1A1TDP1 | |
| SCHEMBL24313994 | 0.72 | HTT (0.56) | BACE1ADORA3FPR1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108101845-B | Preparation method of eltrombopag | 苏州科伦药物研究有限公司 | 2020-05-15 | — | — | CN | disclosed |