Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | RORB | Q92753 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CFD | P00746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28418983 | 0.83 | BACE1 (0.46) | BACE1LMNAALDH1A1HSD17B10HPGD | |
| SCHEMBL27999721 | 0.80 | CYP3A4 (0.57) | BACE1CYP3A4LMNAALDH1A1HSD17B10 | |
| SCHEMBL3453107 | 0.75 | LMNA (0.50) | BACE1CYP3A4ELANELMNAALDH1A1 | |
| SCHEMBL14710190 | 0.75 | LMNA (0.46) | BACE1CYP3A4ELANELMNAALDH1A1 | |
| SCHEMBL28414986 | 0.73 | EGFR (0.50) | LMNAALDH1A1HPGDPOLBMAPT | |
| SCHEMBL5534885 | 0.73 | LMNA (0.45) | BACE1CYP3A4ELANELMNAALDH1A1 | |
| SCHEMBL9780981 | 0.72 | CFD (0.55) | BACE1CYP3A4ELANELMNAHSD17B10 | |
| SCHEMBL27725727 | 0.72 | CYP3A4 (0.53) | BACE1CYP3A4ELANELMNAHSD17B10 | |
| SCHEMBL28409543 | 0.72 | ALDH1A1 (0.47) | CYP3A4LMNAALDH1A1HSD17B10HPGD | |
| SCHEMBL27935472 | 0.71 | BACE1 (0.70) | BACE1CYP3A4ELANELMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108101845-B | Preparation method of eltrombopag | 苏州科伦药物研究有限公司 | 2020-05-15 | — | — | CN | disclosed |