Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 5/20 | 0.34 |
| ▸ | PARP1 | P09874 | 4/20 | 0.34 |
| ▸ | JAK2 | O60674 | 4/20 | 0.33 |
| ▸ | JAK1 | P23458 | 3/20 | 0.33 |
| ▸ | JAK3 | P52333 | 3/20 | 0.33 |
| ▸ | CD38 | P28907 | 2/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28423225 | 0.80 | AURKA (0.44) | SYK | |
| SCHEMBL27718225 | 0.69 | KMT2A (0.39) | — | |
| SCHEMBL25781766 | 0.69 | PIM1 (0.40) | KDM4ETYK2PARP1JAK2JAK1 | |
| SCHEMBL27913740 | 0.69 | ADORA3 (0.45) | PARP1 | |
| SCHEMBL1272593 | 0.68 | — | — | |
| SCHEMBL342602 | 0.65 | RAB9A (0.39) | KDM4E | |
| SCHEMBL10126699 | 0.64 | EML4 (0.34) | TYK2SYK | |
| SCHEMBL402279 | 0.64 | — | — | |
| SCHEMBL16247169 | 0.63 | KDM4E (0.47) | NNMTKDM4EPARP1MAP4K4SYK | |
| SCHEMBL2832331 | 0.63 | ALDH1A1 (0.59) | KDM4EDHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101103017-A | Novel aminopyridine derivatives having Aurora-A selective inhibitory action | BANYU PHARMA CO LTD (JP) | 2008-01-09 | — | — | CN | disclosed |